Engineered organs and tissues have been developed with different levels of success for many years in labs. Many of them have employed a scaffolding method where cells are seeded onto supportive biodegradable structures that offer the underlying structure of the tissue or organ desired.
But scaffolds can be challenging. Eventually, they must disappear or degrade, but timing that decomposition to match with the growth of the organ is difficult, and sometimes degradation residues can be poisonous. Scaffolds also can meddle with the growth of cell-to-cell links, which are essential for the making of operational tissues.
Now, a study group spearheaded by the Richard and Loan Hill Professor at the University of Illinois for Orthopaedics and Bioengineering at Chicago, Eben Alsberg, has designed a procedure that allows biological tissues’ 3D printing without scaffolds employing “ink” made composed of only stem cells. They report their outcomes in the Materials Horizons journal.
“Our cell-only printing service enables the cells’ 3D printing without a traditional scaffold support employing a temporary hydrogel bead bath in which printing occurs,” Alsberg claimed. The hydrogel micron-scale beads let the nozzle of the 3D printer to flow all over it and place cells with the ejection of the cells or negligible resistance to that nozzle movement. The gel beads show support for the cells as they are printed and holds them in position and maintain their shape.
On a related note, research team at DGIST was successful in designing delivery of stem cell for scaffold1 microrobot that can accurately deliver cells to a target tissue in a body. This study achievement is anticipated to improve the treatment efficiency and safety of degenerative neural diseases as it can accurately transplant the precise number of stem cell-supported treatment cells to human body organs and tissues. This can further improve the current treatment efficiency of stem cell.
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